400 million

Glucose-6-Phosphate-Dehydrogenase Deficiency (G-6-PD) is a genetic deficiency that causes red blood cells to hemolyze in the presence of certain drugs or chemicals, infections or other stressors. Statistically determined to affect more than four hundred million people globally, mostly people of African and Middle Eastern descent. When triggered, symptoms include fever, dark colored urine, abdominal and back pain, fatigue, and pale skin. It has been linked with maleria, and various organ failures including kidney failure. It can easily be confused with hard to isolate auto immune diseases such as ahus.
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400 million

Unread post by majestik » Thu Dec 27, 2018 5:41 pm

The G6P gene deficiency affects more than 400 million people worldwide, most of them male (more than 95%) and most of them middle easterners and africans. People who are G6P deficient are advised to stay away from its triggers. Interestingly, many of these triggers are either drugs commonly used to treat various known health conditions (such as quinine for malaria) or staple food such as fava beans.Image

It is therefore imperative that public service announcements be made in these regions of the world (and every where to be honest) to sensitize people to the basic danger they face just by being themselves.

400 million is more than 50% of all African male. G6P deficiency (G6PD) while so prevalent, is not widely tested for even in patients presenting many of the symptoms, including hemolytic anemia. So a person who is exposed to the triggers may not even be aware of the danger they are facing. Fava beans for example is a common culinary staple in middle east and north Africa region and even the sick eat them. Quinine is a popular anti-malaria drug used in malaria prone regions of west and central Africa, but it is also a trigger of G6PD.

During a flare up, patients hemolyse faster leading to anemia. If the trigger is not removed quickly, it could lead to organ damage or death. Other triggers include basic infections. Quickly treating the infection will limit the risk of further damage.